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Vol. 10 No. 1, January 2009
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NeoReviews Vol.10 No.1 2009 e20
© 2009 American Academy of Pediatrics

Retinopathy of Prematurity

Recent Developments

Brian W. Fleck, MD, FRCS, FRCOph*
Neil McIntosh, DSc(Med), MRCP{dagger}

* Consultant Ophthalmologist, Department of Neonatology, Simpson's Centre for Reproductive Health, Royal Infirmary, Edinburgh, United Kingdom; Royal Hospital for Sick Children, Edinburgh, United Kingdom
{dagger} Emeritus Professor of Child Life and Health, University of Edinburgh; Department of Neonatology, Simpson's Centre for Reproductive Health, Royal Infirmary, Edinburgh, United Kingdom

Retinopathy of prematurity (ROP) is a disorder of retinal vascular development in preterm infants. It remains a major cause of childhood blindness worldwide. This review addresses advances in knowledge during the past 8 years. The pathogenesis has become clearer with animal experimental work and from clinical observations. Large clinical trials have informed better management, and new retinal digital imaging is likely to change the role of the ophthalmologist. New treatment modalities, such as vascular endothelial growth factor (VEGF)-blocking antibodies, are being assessed. Finally, a number of evidence-based clinical guidelines for the management of ROP have been published.

Abbreviations: AP-ROP: aggressive posterior ROP • BIO: binocular indirect ophthalmoscope • ETROP: Early Treatment of ROP • IGF-1: insulin-like growth factor-1 • ROP: retinopathy of prematurity • SGA: small for gestational age • VEGF: vascular endothelial growth factor


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