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Vol. 10 No. 3, March 2009
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NeoReviews Vol.10 No.3 2009 e121
© 2009 American Academy of Pediatrics

Bedside Cerebral Monitoring to Predict Neurodevelopmental Outcomes

Valerie Y. Chock, MD*
Alexis S. Davis, MD*

* Division of Neonatal-Developmental Medicine, Stanford University, Palo Alto, Calif

Emerging neurodiagnostic technologies for bedside application allow earlier detection of neonatal cerebral injury, especially in critically ill infants for whom advanced neuroimaging may not be feasible. To date, no single bedside cerebral monitoring technique has been shown to provide early, accurate prediction of neurodevelopmental outcome in neonates. Multimodal cerebral monitoring may improve predictive capabilities by combining measurements of cerebral function such as electrical activation, oxygenation, and autoregulation of blood flow. This review focuses on two specific cerebral monitoring techniques that are easy to apply in a neonatal intensive care unit (NICU) and amenable to interpretation by a neonatologist who has limited training: aEEG and NIRS. Their role in the prediction of neurodevelopmental outcomes is discussed.

Abbreviations: aEEG: amplitude-integrated encephalography • CNS: central nervous system • ECMO: extracorporeal membrane oxygenation • ELBW: extremely low birthweight • FTOE: fractional tissue oxygen extraction • HbD: hemoglobin difference signal • HIE: hypoxic-ischemic encephalopathy • IVH: intraventricular hemorrhage • MAP: mean arterial blood pressure • MRI: magnetic resonance imaging • NICU: neonatal intensive care unit • NIRS: near-infrared spectroscopy • PHH: posthemorrhagic hydrocephalus • PPI: pressure passive index • PPV: positive predictive value • PVL: periventricular leukomalacia • rSO2: regional cerebral oxygen saturation • SWC: sleep-wake cycle


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