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NeoReviews Vol.10 No.3 2009 e121
© 2009 American Academy of Pediatrics
* Division of Neonatal-Developmental Medicine, Stanford University, Palo Alto, Calif
Emerging neurodiagnostic technologies for bedside application allow earlier detection of neonatal cerebral injury, especially in critically ill infants for whom advanced neuroimaging may not be feasible. To date, no single bedside cerebral monitoring technique has been shown to provide early, accurate prediction of neurodevelopmental outcome in neonates. Multimodal cerebral monitoring may improve predictive capabilities by combining measurements of cerebral function such as electrical activation, oxygenation, and autoregulation of blood flow. This review focuses on two specific cerebral monitoring techniques that are easy to apply in a neonatal intensive care unit (NICU) and amenable to interpretation by a neonatologist who has limited training: aEEG and NIRS. Their role in the prediction of neurodevelopmental outcomes is discussed.
Abbreviations: aEEG: amplitude-integrated encephalography CNS: central nervous system ECMO: extracorporeal membrane oxygenation ELBW: extremely low birthweight FTOE: fractional tissue oxygen extraction HbD: hemoglobin difference signal HIE: hypoxic-ischemic encephalopathy IVH: intraventricular hemorrhage MAP: mean arterial blood pressure MRI: magnetic resonance imaging NICU: neonatal intensive care unit NIRS: near-infrared spectroscopy PHH: posthemorrhagic hydrocephalus PPI: pressure passive index PPV: positive predictive value PVL: periventricular leukomalacia rSO2: regional cerebral oxygen saturation SWC: sleep-wake cycle
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