Neoreviews
HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Take the CME quiz:
 Vol. 10 No. 4, April 2009
Right arrow E-Letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-Letters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gareau, M. G.
Right arrow Articles by Sherman, P. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Gareau, M. G.
Right arrow Articles by Sherman, P. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

NeoReviews Vol.10 No.4 2009 e191
© 2009 American Academy of Pediatrics

Early Life Stress Induces Both Acute and Chronic Colonic Barrier Dysfunction

Mélanie G. Gareau, PhD*
Eytan Wine, MD, PhD*
Philip M. Sherman, MD*

* Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada

Exposure to stress in early life can have a profound impact on health in later life, including intestinal pathology. Maternal separation is a well-established and reproducible model of early life stress in rodents that leads to the development of mood disorders and altered intestinal function, including visceral hypersensitivity, colonic dysmotility, and increased intestinal permeability. In this article, we highlight the consequences of disruption of normal programming after exposure to maternal separation in neonates: the development of intestinal alterations in both neonatal and adult animals as well as the accompanying behavioral changes. Mechanisms of action include corticotropin-releasing factor (CRF) and nerve growth factor (NGF), which signal both in the brain and in the periphery. Exposure to stress in early life also can alter bacterial colonization, which is prevented by treatment with probiotic organisms. We conclude by highlighting the link between stress and colonic permeability in humans, including the increased risk of disease relapse in irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD).

Abbreviations: ACTH: adrenocorticotropin hormone • CNS: central nervous system • CRF: corticotropin-releasing factor • ENS: enteric nervous system • GC: glucocorticoid • HPA: hypothalamus-pituitary-adrenal • IBD: inflammatory bowel diseases • IBS: irritable bowel syndrome • IL: interleukin • MS: maternal separation • NEC: necrotizing enterocolitis • NGF: nerve growth factor • NS: nonseparated • WAS: water avoidance stress


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the American Academy of Pediatrics.