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Vol. 10 No. 5, May 2009
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NeoReviews Vol.10 No.5 2009 e222
© 2009 American Academy of Pediatrics

Neonatal Abstinence Syndrome

Anthony E. Burgos, MD, MPH*
Bryan L. Burke, Jr, MD{dagger}

* Department of Pediatrics, Stanford University, Palo Alto, Calif
{dagger} Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Ark

Despite the growing knowledge of recognition, treatment, and outcomes, NAS continues to challenge clinicians. An increasing number of women receiving prescribed medications for chronic pain conditions and mental illness also have changed the population needing prenatal counseling and postnatal monitoring. NAS develops in more than 50% of all newborns exposed to narcotics in utero, but the signs of withdrawal remain nonspecific, and couplet care or rooming-in on postpartum wards often hinders monitoring and evaluation. Several abstinence scoring systems can assist nurses and physicians in assessing the severity of withdrawal and providing appropriate therapy. Medical therapy is recommended for severe cases, and several medications have proven safe and effective. Although the duration of therapy varies, medications can be titrated so infants can tolerate mild symptoms of withdrawal, and the process can be monitored with abstinence scores. This article reviews the signs of NAS from various substances, existing abstinence scoring systems, current treatment and weaning strategies, and relevant points for prenatal counseling.


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