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 Vol. 10 No. 9, September 2009
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NeoReviews Vol.10 No.9 2009 e454
© 2009 American Academy of Pediatrics

Preeclampsia and Neonatal Neutropenia

Mohannad Moallem, MD*
Joyce M. Koenig, MD{dagger}

* Fellow, Neonatal-Perinatal Medicine, Department of Pediatrics, Saint Louis University, St. Louis, Mo
{dagger} Professor of Pediatrics, Molecular Microbiology & Immunology, Associate Chair for Research, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Saint Louis University, St. Louis, Mo

Neutropenia is a common hematologic disorder in the newborn intensive care unit, particularly in preterm neonates. Although its cause varies, a significant proportion of the episodes are associated with pregnancy complicated by preeclampsia. In this review, we provide a brief overview of preeclampsia and neonatal neutropenia, with a focus on the neonatal neutropenia associated with maternal preeclampsia. We discuss potential contributory mechanisms to and the natural history of this type of neutropenia, as well as reasonable management strategies in affected neonates.

Abbreviations: ANC: absolute neutrophil count • G-CSF: granulocyte colony-stimulating factor • HELLP: syndrome of hemolysis, elevated liver enzymes, low platelets • NICU: neonatal intensive care unit • PIH: pregnancy-induced hypertension • SGA: small for gestational age • VLBW: very low birthweight


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