Neoreviews
HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Take the CME quiz:
 Vol. 8 No. 10, October 2007
Right arrow E-Letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-Letters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Limperopoulos, C.
Right arrow Articles by du Plessis, A. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Limperopoulos, C.
Right arrow Articles by du Plessis, A. J.

NeoReviews Vol.8 No.10 2007 e409
© 2007 American Academy of Pediatrics

Injury to the Developing Cerebellum

Mechanisms and Consequences

Catherine Limperopoulos, PhD*
Adré J. du Plessis, MBChB, MPH{dagger}

* Canada Research Chair in Brain and Development; Assistant Professor, Department of Neurology and Neurosurgery, School of Physical and Occupational Therapy, and Department of Pediatrics, McGill University, Montreal, Quebec, Canada; Fetal-Neonatal Neurology Research Group, Children's Hospital Boston, Boston, Mass
{dagger} Senior Associate in Neurology; Director, Fetal-Neonatal Neurology Research Group, Children's Hospital Boston; Associate Professor of Neurology, Harvard Medical School, Boston, Mass

Advances in neuroimaging techniques for the in vivo study of brain development have expanded the understanding of normal and abnormal cerebellar development in the high-risk fetus and newborn. This, in turn, has provided new insights into the spectrum of structural and functional consequences of injury to the developing cerebellum. Specifically, hemorrhagic cerebellar lesions in preterm infants are associated with significant impairment of subsequent cerebellar growth as well as impaired growth of the contralateral cerebral hemisphere. Furthermore, preterm extrauterine life appears to inhibit cerebellar growth, even in the absence of obvious primary injury. Recent long-term outcome studies in preterm infants who had cerebellar injury suggest a distinct profile of pervasive neurodevelopmental deficits, with a high prevalence of cognitive-behavioral dysfunction. The structure-function relationships between early cerebellar injury and long-term outcome are a fertile area for future research.






HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Academy of Pediatrics.