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 Vol. 8 No. 3, March 2007
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NeoReviews Vol.8 No.3 2007 e127
© 2007 American Academy of Pediatrics

Assisted Reproductive Technology and Preimplantation Genetic Diagnosis

Impact on the Fetus and Newborn

Janet M. Cowan, PhD*
Laurie A. Demmer, MD*

* Division of Genetics, Department of Pediatrics, Tufts-New England Medical Center, Boston, Mass

Assisted reproductive technology (ART) techniques have enabled couples with low fertility to conceive, and approximately 1% of births in the United States result from such procedures. ART combined with preimplantation genetic diagnosis (PGD) has provided a method for couples at risk for genetic conditions to deliver a baby free from the condition. ART presents many perinatal risks and may be associated with long-term health effects for the offspring. PGD, which can screen for known conditions, at present cannot screen for all genetic conditions.

Abbreviations: ART: assisted reproductive technology • CDC: Centers for Disease Control and Prevention • FISH: fluorescent in situ hybridization • HIV: human immunodeficiency virus • ICSI: intracytoplasmic sperm injection • IVF: in vitro fertilization • PCR: polymerase chain reaction • PGD: preimplantation genetic diagnosis


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Copyright © 2007 by the American Academy of Pediatrics.