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 Vol. 8 No. 5, May 2007
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NeoReviews Vol.8 No.5 2007 e214
© 2007 American Academy of Pediatrics

Pharmacology Review

Clinical Pharmacology of Caffeine in the Newborn

Girija Natarajan, MD*
Mirjana Lulic-Botica, RPh*
J.V. Aranda, MD, PhD*

* Divisions of Neonatology, Clinical Pharmacology and Toxicology, The Pediatric Pharmacology Research Unit Network (PPRU) at Wayne State University, Children's Hospital of Michigan, Detroit, Mich

Caffeine is used commonly in the neonatal intensive care unit to treat apnea of prematurity. This review describes the mechanism of action, pharmacokinetics, and therapeutic role of caffeine. Published data on its efficacy and safety document that caffeine can reduce the frequency of apneic episodes and appears safe in the short term.


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Copyright © 2007 by the American Academy of Pediatrics.