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 Vol. 8 No. 8, August 2007
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NeoReviews Vol.8 No.8 2007 e336
© 2007 American Academy of Pediatrics

The Genomics of Bronchopulmonary Dysplasia

Vineet Bhandari, MD, DM*
Jeffrey R. Gruen, MD*,{dagger}

* Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Conn
{dagger} Departments of Genetics and Investigative Medicine, Yale Child Health Research Center, New Haven, Conn

Bronchopulmonary dysplasia continues to be a major cause of neonatal morbidity, despite significant progress in the treatment of preterm neonates. The cause is multifactorial, with prematurity as the primary culprit and other factors including ventilator-induced lung injury, exposure to oxygen, and inflammation. Recent studies in twins show that 53% of the variance is attributable to genetic factors. In this review, we critically evaluate published association studies of candidate gene polymorphisms.

Abbreviations: ACE: angiotensin-converting enzyme • BAL: bronchoalveolar lavage • BPD: bronchopulmonary dysplasia • DZ: dizygotic • GST: glutathione S transferase • IGF-1: insulin-like growth factor 1 • IGF-1R: insulin-like growth factor-1 receptor • IFN: interferon • IL: interleukin • MCP: monocyte chemoattractant protein • MZ: monozygotic • O2: oxygen • PMA: postmenstrual age • RDS: respiratory distress syndrome • SNP: single nucleotide polymorphism • SP: surfactant protein • TAP: transporter associated with antigen processing • TGF: transforming growth factor • TNF: tumor necrosis factor • VLBW: very low birthweight






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