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 Vol. 8 No. 9, September 2007
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NeoReviews Vol.8 No.9 2007 e368
© 2007 American Academy of Pediatrics

Developmental Defects in Neutrophils from Preterm Infants

Sharat Chandra, MD, MRCPCH*
Hillary Haines, MD{dagger}
Colin Michie, FRCPCH{ddagger}
Akhil Maheshwari, MD{dagger},§

* Department of Pediatrics, University of South Alabama, Mobile, Ala
{dagger} Department of Pediatrics, University of Alabama at Birmingham, Ala
{ddagger} Department of Paediatrics, Ealing Hospital, NHS Trust, London, United Kingdom
§ Department of Cell Biology, University of Alabama at Birmingham, Ala

Neutrophil development starts in the early second trimester in the human fetus and continues through the rest of the gestation. Preterm birth can interrupt the maturation of fetal neutrophils and place the preterm neonate at risk of life-threatening infections. Various developmental defects have been identified in preterm neutrophils, such as in the ability of circulating neutrophils to cross the endothelial barrier and abnormalities in chemotaxis, respiratory burst, and degranulation. The availability of recombinant human myeloid growth factors has renewed interest in understanding the mechanisms and natural history of such defects. In this article, we review various aspects of the developmental immaturity of preterm neutrophils.






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Copyright © 2007 by the American Academy of Pediatrics.