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 Vol. 9 No. 10, October 2008
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NeoReviews Vol.9 No.10 2008 e447
© 2008 American Academy of Pediatrics

Inflammation and Lung Disease in the Neonatal Period

Bradley A. Yoder, MD*
Kurt H. Albertine, PhD{dagger}

* Professor of Pediatrics, Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
{dagger} Professor of Pediatrics, Medicine, and Neurobiology & Anatomy, Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salk Lake City, Utah

A variety of insults can contribute to lung inflammation in the neonatal period. Many of these insults exert their effects through activation or suppression of critical transcription factor pathways. The effect of these pathways on gene transcription/protein translation has a direct impact on lung development, labor induction and the intra-amniotic milieu, and postnatal lung inflammation.

Abbreviations: BMP: bone morphogenetic protein • BPD: bronchopulmonary dysplasia • FGF: fibroblast growth factor • I kappa B: inhibitor kappa B • IL: interleukin • iNOS: inducible nitric oxide synthase • LPS: lipopolysaccharide • NF-kappa B: nuclear factor-kappa B • PGI: prostaglandin • PPAR: peroxisome proliferator-activated receptor • PTHrP: parathyroid hormone-related protein • RDS: respiratory distress syndrome • RXR: retinoic acid receptor • Shh: sonic hedgehog • TGF: transforming growth factor • TLR: toll-like receptor • TNF: tumor necrosis factor






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