Neoreviews
HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Take the CME quiz:
 Vol. 9 No. 2, February 2008
Right arrow E-Letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-Letters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Forghani, N.
Right arrow Articles by Aye, T.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Forghani, N.
Right arrow Articles by Aye, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

NeoReviews Vol.9 No.2 2008 e66
© 2008 American Academy of Pediatrics

Hypothyroxinemia and Prematurity

Nikta Forghani, MD*
Tandy Aye, MD*

* Division of Endocrinology, Department of Pediatrics, Stanford University, Palo Alto, Calif

The growing fetus relies on adequate thyroid hormone concentrations for normal development, which is dependent on maternal transplacental thyroid hormone passage and the appropriate development of the fetal hypothalamic-pituitary-thyroid axis. Untreated congenital hypothyroidism can result in severe neurodevelopmental disabilities, including mental retardation, auditory dysfunction, and spastic diplegia. Most outcomes data also suggest that up to 10% of infants treated early in the era of newborn screening still have long-term disabilities, although they are minor. Preterm infants have lower serum concentrations of thyroid hormones compared with their term counterparts early in postnatal life, and there has been a concern that this transient hypothyroxinemia could be partially responsible for the neurodevelopmental impairment associated with prematurity. Therefore, a number of investigators have examined this relationship and the potential use of thyroid hormone in preterm infants to improve neurodevelopmental outcomes. This article reviews this literature and discusses possible directions for the future.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Academy of Pediatrics.