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 Vol. 9 No. 2, February 2008
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NeoReviews Vol.9 No.2 2008 e72
© 2008 American Academy of Pediatrics

Adrenal and Pituitary Insufficiency in the Neonate

David Dempsher, MD, PhD*

* Associate Professor of Pediatrics, Divisions of Pediatric Endocrinology and General Academic Pediatrics, Saint Louis University School of Medicine, St Louis, Mo

Adrenal and pituitary deficiency can present catastrophically with shock and cardiopulmonary arrest or gradually with lethargy and failure to thrive. Lifesaving treatment is safe and simple, and timely recognition of the disorder minimizes the likelihood of death or permanent brain injury from hypoglycemia and hypothyroidism. This article reviews the major causes and clinical presentations of adrenal and pituitary deficiency states in the newborn period as well as evaluation of pituitary and adrenal function and the principles of endocrine replacement therapy.






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Copyright © 2008 by the American Academy of Pediatrics.