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 Vol. 9 No. 5, May 2008
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NeoReviews Vol.9 No.5 2008 e192
© 2008 American Academy of Pediatrics

Chemokines and Cytokines

A Primer of Cellular Biology for the Clinical Neonatologist

Reed A. Dimmitt, MD, MSPH*

* Departments of Pediatrics, Surgery, and Microbiology, University of Alabama at Birmingham

The developing fetus that exists in a privileged and relatively sterile environment has no major requirement for protection against invading organisms or other mechanisms of injury. When that fetus transforms into a preterm infant, survival necessitates rapid activation of immune function. The systemic and mucosal immune response is orchestrated by myriad locally functioning chemicals called chemokines and cytokines. This article reviews the structure, function, and cellular population of these compounds as well as their roles in the development or protection against the diseases of preterm infants.


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Copyright © 2008 by the American Academy of Pediatrics.