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This Article Full Text Full Text (PDF) Take the CME quiz: Vol. 9 No. 9, September 2008 E-Letters: Submit a response Alert me when this article is cited Alert me when E-Letters are posted Alert me if a correction is posted Citation Map Services E-mail this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Faye-Petersen, O. M. Articles by Crombleholme, T. M. PubMed Articles by Faye-Petersen, O. M. Articles by Crombleholme, T. M.

NeoReviews Vol.9 No.9 2008 e393
© 2008 American Academy of Pediatrics

Twin-to-Twin Transfusion

Part 3. Mortality and Neurodevelopmental Outcomes Following Intervention

Ona M. Faye-Petersen, MD^*
Timothy M. Crombleholme, MD

^* Associate Professor of Pathology and Obstetrics and Gynecology; Head, Microdissection Laboratory, Division of Anatomic Pathology, The University of Alabama at Birmingham, Birmingham Ala
Director, Fetal Care Center of Cincinnati; Professor of Surgery, Pediatrics, and Obstetrics and Gynecology, University of Cincinnati College of Medicine; Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

The high morbidity and mortality rates of twin-to-twin transfusion syndrome (TTTS) generally are related to sequelae of cardiovascular dysfunction or vascular disruption. Neurologic sequelae associated with TTTS are emerging concerns for survivors. A variety of clinical interventions, including amnioreduction, microseptostomy of the inter-twin membrane, and fetoscopic laser photocoagulation of placental anastomoses, have been used alone or in sequence to reduce the rates of mortality and morbidity. Because many of these specialized interventional procedures are performed at select centers in the United States, women may be treated at considerable distance from their primary obstetric care institutions and later return to deliver at their local facilities. Neonatologists may be unfamiliar with the relative efficacies and outcomes of the interventional procedures. In this review, we present a focused summary of the neurodevelopmental outcomes associated with these antenatal treatments.