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NeoReviews Vol.8 No.8 2007 e311
© 2007 American Academy of Pediatrics
| The first 20% of the full text of this article appears below. |
| High-altitude Cardiopulmonary Physiology |
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Sir JB, as he was affectionately called, was born into a Quaker family on July 26, 1872 at the Glen, Newry, County Down, in today's Northern Ireland. Schooling was at Bootham, York, and later at the Leys School in Cambridge. After earning a degree in Science from London in 1891, JB opted for a career in physiology, rather than medicine, and took up a job as a lecturer at Cambridge's King's College in 1900. He became a Fellow of the Royal College in 1911.
During much of his professional life, Sir JB worked on high-altitude cardiopulmonary physiology. He was a quintessential "guinea pig scientist." To study the effects of hypoxia, he made himself an experimental subject. In 1920, he built a glass chamber and lived in it for 6 days, Inside the chamber, the PO2 had been dropped to 84 mm Hg,
* Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md
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