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<title>NeoReviews current issue</title>
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<description>Pediatrics RSS feed -- current issue</description>
<prism:eIssn>1526-9906</prism:eIssn>
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<title>NeoReviews</title>
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<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e527?rss=1">
<title><![CDATA[Neonatal Informatics--Dream of a Paperless NICU: Part Two: Understanding Clinical Expertise]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e527?rss=1</link>
<description><![CDATA[
<P>Expert versus novice clinical data gathering, cognitive modeling strategies, and physical skills for evaluating medical problems differ markedly in complexity, clinical accuracy, and speed. Experts&rsquo; mental models develop during a decade of education <I>and</I> practical training. Clinical experts use data-based clinical information flow in near real-time to assess complex intensive care unit (ICU) situations and to act definitively and correctly within 2 to 30 seconds of acute problem recognition. Critical care bedside medical management of unstable neonates, when parents are present, challenges all existing clinical processes and computerized information systems. Success is currently-site dependent. Details are very important.</P>
<P>The critical care expert's working mental model is a temporally sequenced, multidimensional, physiologically based matrix, in which 20 to 60 simultaneous clinical variables can be assimilated nearly instantaneously. The mental data-seeking exercise follows an expert's cognitive pattern of simultaneously developing answers, while still seeking more data. Any computerized, paperless incarnation of clinical data management in NICUs should have instant data access at the bedside for full support of focused, expert-level, cognitive work and decision making. High-speed information reporting is essential in all ICU environments.</P>
<P>Critical care clinicians often are interrupted by a more urgent situation. Standard computer access/use/log-off is very difficult to incorporate seamlessly into a NICU workflow. Critical care physicians report feeling cognitively blinded by computer-related fragmentation of the temporally flowing clinical data streams. Nurses are distracted by time-consuming, adult-designed charting systems requiring typed data entry. Reports are slow and fragmented.</P>
<P>Neonatologists and criticalists find that existing computerized charting methods in NICUs waste time. Without bedside data tracking, quick understanding of the overall situation of a particular patient, at the bedside, at a particular moment is virtually impossible. New computerization introduces change that often disrupts generations-old clinical workflow functions and may have many unintended consequences. Planning, developing, or purchasing and implementing effective systems for totally computerizing an NICU is an interdisciplinary work in progress.</P>
]]></description>
<dc:creator><![CDATA[Drummond, W. H.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e527</dc:identifier>
<dc:title><![CDATA[Neonatal Informatics--Dream of a Paperless NICU: Part Two: Understanding Clinical Expertise]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e537</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e527</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e538?rss=1">
<title><![CDATA[Comprehensive First-trimester Prenatal Assessment]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e538?rss=1</link>
<description><![CDATA[
<P>Comprehensive first-trimester pregnancy evaluation is a work in progress. The evolution of screening strategies has distilled a combination of maternal factors, early pregnancy analytes in maternal serum, and fetal sonographic parameters into carefully derived risk assessment algorithms. This integrated approach, almost continually supplemented by new information derived from large population-based studies, individualizes assessment to each mother-placenta-fetus triad. Early and accurate, this assessment potentiates informed decision-making and prenatal management. Invasive testing can be limited to those at high risk, decreasing procedure-related losses of unaffected fetuses. Advance warning of preeclampsia and other placenta-based disorders allows stratification of care and opens new windows to prevention therapy. Viewing of anomalies, even complex congenital heart disease, using the steadily advancing three- and four-dimensional capabilities now available, allows prenatal diagnosis and intrauterine surgical management. Comprehensive risk assessment in early pregnancy is transforming prenatal care.</P>
]]></description>
<dc:creator><![CDATA[Miller, J., Harman, C.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e538</dc:identifier>
<dc:title><![CDATA[Comprehensive First-trimester Prenatal Assessment]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e549</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e538</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e550?rss=1">
<title><![CDATA[Retinopathy of Prematurity: Clinical Insights from Molecular Studies]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e550?rss=1</link>
<description><![CDATA[
<P>Retinopathy of prematurity (ROP) is a clinically multifactorial process characterized by the aberrant vascularization of the retina that has potentially devastating effects on vision in preterm infants. Despite an appreciation for the postnatal risk factors that contribute to the development of ROP, this condition continues to be a major cause of childhood blindness. Studies using the mouse model of oxygen-induced retinopathy (OIR) have identified new therapeutic targets that may be used to guide treatment and determine which babies are at highest risk for ROP development. Such factors include the hypoxia-driven proteins vascular endothelial growth factor (VEGF) and erythropoietin (EPO) as well as the maternally derived factors insulin-like growth factor-1 (IGF-1) and omega-3 polyunsaturated fatty acids (PUFAs). Each has been demonstrated to have phase-specific effects on the pathogenesis of ROP. Through an understanding of the contribution of the IGF-1 pathway to the development of ROP in particular, a new algorithm has been developed (WINROP<SUP><SMALL><SMALL>TM</SMALL></SMALL></SUP>) that uses postnatal weight gain to identify infants at highest risk for ROP in an attempt to target therapy and resources more effectively.</P>
]]></description>
<dc:creator><![CDATA[Heidary, G., Lofqvist, C., Mantagos, I. S., Vanderveen, D. K., Hellstrom, A., Smith, L. E.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Disorders of the Eye]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e550</dc:identifier>
<dc:title><![CDATA[Retinopathy of Prematurity: Clinical Insights from Molecular Studies]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e557</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e550</prism:startingPage>
<prism:section>Articles</prism:section>
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<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e558?rss=1">
<title><![CDATA[Dogma Disputed: Why Intravenous Sodium Bicarbonate Doesn't Work]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e558?rss=1</link>
<description><![CDATA[
<P>Sodium bicarbonate is an ideal buffer for the treatment of metabolic acidosis if the following conditions are present: 1) the desired pH is close to 6.1, 2) the recipient has the ability to excrete instantly any additional carbon dioxide generated, and 3) the additional osmoles do not shift the pK<SUB>a</SUB> of all buffers downward. Unfortunately, none of these three conditions are met. Intravenous sodium bicarbonate might provide a benefit if the patient who has metabolic acidosis needs more extracellular fluid volume (eg, those who have lactic acidosis). However, in trials comparing the effect of sodium bicarbonate with sodium chloride or albumin, sodium bicarbonate was not superior. Consequently, the intravenous administration of sodium bicarbonate is not recommended for the treatment of newborns who have metabolic acidosis.</P>
]]></description>
<dc:creator><![CDATA[Poland, R. L.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Metabolic Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e558</dc:identifier>
<dc:title><![CDATA[Dogma Disputed: Why Intravenous Sodium Bicarbonate Doesn't Work]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e563</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e558</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/11/e564?rss=1">
<title><![CDATA[Index of Suspicion in the Nursery: My Baby is Breathing Funny and Won't Eat]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/11/e564?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Posner, K. R.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Metabolic Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e564</dc:identifier>
<dc:title><![CDATA[Index of Suspicion in the Nursery: My Baby is Breathing Funny and Won't Eat]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e566</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e564</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/11/e567?rss=1">
<title><![CDATA[Strip of the Month: November 2009]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/11/e567?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Druzin, M. L., Peterson, N.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e567</dc:identifier>
<dc:title><![CDATA[Strip of the Month: November 2009]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e574</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e567</prism:startingPage>
<prism:section>Articles</prism:section>
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<item rdf:about="http://neoreviews.aappublications.org/cgi/content/short/10/11/e575?rss=1">
<title><![CDATA[Visual Diagnosis: Skin Ulcerations in a Preterm Newborn (Click here)]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/short/10/11/e575?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Wambach, J., Morley, S. C.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e575</dc:identifier>
<dc:title><![CDATA[Visual Diagnosis: Skin Ulcerations in a Preterm Newborn (Click here)]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e575</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e575</prism:startingPage>
<prism:section>Visual Diagnosis</prism:section>
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