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<title>NeoReviews</title>
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<link>http://neoreviews.aappublications.org</link>
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<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e527?rss=1">
<title><![CDATA[Neonatal Informatics--Dream of a Paperless NICU: Part Two: Understanding Clinical Expertise]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e527?rss=1</link>
<description><![CDATA[
<P>Expert versus novice clinical data gathering, cognitive modeling strategies, and physical skills for evaluating medical problems differ markedly in complexity, clinical accuracy, and speed. Experts&rsquo; mental models develop during a decade of education <I>and</I> practical training. Clinical experts use data-based clinical information flow in near real-time to assess complex intensive care unit (ICU) situations and to act definitively and correctly within 2 to 30 seconds of acute problem recognition. Critical care bedside medical management of unstable neonates, when parents are present, challenges all existing clinical processes and computerized information systems. Success is currently-site dependent. Details are very important.</P>
<P>The critical care expert's working mental model is a temporally sequenced, multidimensional, physiologically based matrix, in which 20 to 60 simultaneous clinical variables can be assimilated nearly instantaneously. The mental data-seeking exercise follows an expert's cognitive pattern of simultaneously developing answers, while still seeking more data. Any computerized, paperless incarnation of clinical data management in NICUs should have instant data access at the bedside for full support of focused, expert-level, cognitive work and decision making. High-speed information reporting is essential in all ICU environments.</P>
<P>Critical care clinicians often are interrupted by a more urgent situation. Standard computer access/use/log-off is very difficult to incorporate seamlessly into a NICU workflow. Critical care physicians report feeling cognitively blinded by computer-related fragmentation of the temporally flowing clinical data streams. Nurses are distracted by time-consuming, adult-designed charting systems requiring typed data entry. Reports are slow and fragmented.</P>
<P>Neonatologists and criticalists find that existing computerized charting methods in NICUs waste time. Without bedside data tracking, quick understanding of the overall situation of a particular patient, at the bedside, at a particular moment is virtually impossible. New computerization introduces change that often disrupts generations-old clinical workflow functions and may have many unintended consequences. Planning, developing, or purchasing and implementing effective systems for totally computerizing an NICU is an interdisciplinary work in progress.</P>
]]></description>
<dc:creator><![CDATA[Drummond, W. H.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e527</dc:identifier>
<dc:title><![CDATA[Neonatal Informatics--Dream of a Paperless NICU: Part Two: Understanding Clinical Expertise]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e537</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e527</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e538?rss=1">
<title><![CDATA[Comprehensive First-trimester Prenatal Assessment]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e538?rss=1</link>
<description><![CDATA[
<P>Comprehensive first-trimester pregnancy evaluation is a work in progress. The evolution of screening strategies has distilled a combination of maternal factors, early pregnancy analytes in maternal serum, and fetal sonographic parameters into carefully derived risk assessment algorithms. This integrated approach, almost continually supplemented by new information derived from large population-based studies, individualizes assessment to each mother-placenta-fetus triad. Early and accurate, this assessment potentiates informed decision-making and prenatal management. Invasive testing can be limited to those at high risk, decreasing procedure-related losses of unaffected fetuses. Advance warning of preeclampsia and other placenta-based disorders allows stratification of care and opens new windows to prevention therapy. Viewing of anomalies, even complex congenital heart disease, using the steadily advancing three- and four-dimensional capabilities now available, allows prenatal diagnosis and intrauterine surgical management. Comprehensive risk assessment in early pregnancy is transforming prenatal care.</P>
]]></description>
<dc:creator><![CDATA[Miller, J., Harman, C.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e538</dc:identifier>
<dc:title><![CDATA[Comprehensive First-trimester Prenatal Assessment]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e549</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e538</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e550?rss=1">
<title><![CDATA[Retinopathy of Prematurity: Clinical Insights from Molecular Studies]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e550?rss=1</link>
<description><![CDATA[
<P>Retinopathy of prematurity (ROP) is a clinically multifactorial process characterized by the aberrant vascularization of the retina that has potentially devastating effects on vision in preterm infants. Despite an appreciation for the postnatal risk factors that contribute to the development of ROP, this condition continues to be a major cause of childhood blindness. Studies using the mouse model of oxygen-induced retinopathy (OIR) have identified new therapeutic targets that may be used to guide treatment and determine which babies are at highest risk for ROP development. Such factors include the hypoxia-driven proteins vascular endothelial growth factor (VEGF) and erythropoietin (EPO) as well as the maternally derived factors insulin-like growth factor-1 (IGF-1) and omega-3 polyunsaturated fatty acids (PUFAs). Each has been demonstrated to have phase-specific effects on the pathogenesis of ROP. Through an understanding of the contribution of the IGF-1 pathway to the development of ROP in particular, a new algorithm has been developed (WINROP<SUP><SMALL><SMALL>TM</SMALL></SMALL></SUP>) that uses postnatal weight gain to identify infants at highest risk for ROP in an attempt to target therapy and resources more effectively.</P>
]]></description>
<dc:creator><![CDATA[Heidary, G., Lofqvist, C., Mantagos, I. S., Vanderveen, D. K., Hellstrom, A., Smith, L. E.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Disorders of the Eye]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e550</dc:identifier>
<dc:title><![CDATA[Retinopathy of Prematurity: Clinical Insights from Molecular Studies]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e557</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e550</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e558?rss=1">
<title><![CDATA[Dogma Disputed: Why Intravenous Sodium Bicarbonate Doesn't Work]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/11/e558?rss=1</link>
<description><![CDATA[
<P>Sodium bicarbonate is an ideal buffer for the treatment of metabolic acidosis if the following conditions are present: 1) the desired pH is close to 6.1, 2) the recipient has the ability to excrete instantly any additional carbon dioxide generated, and 3) the additional osmoles do not shift the pK<SUB>a</SUB> of all buffers downward. Unfortunately, none of these three conditions are met. Intravenous sodium bicarbonate might provide a benefit if the patient who has metabolic acidosis needs more extracellular fluid volume (eg, those who have lactic acidosis). However, in trials comparing the effect of sodium bicarbonate with sodium chloride or albumin, sodium bicarbonate was not superior. Consequently, the intravenous administration of sodium bicarbonate is not recommended for the treatment of newborns who have metabolic acidosis.</P>
]]></description>
<dc:creator><![CDATA[Poland, R. L.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Metabolic Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e558</dc:identifier>
<dc:title><![CDATA[Dogma Disputed: Why Intravenous Sodium Bicarbonate Doesn't Work]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e563</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e558</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/11/e564?rss=1">
<title><![CDATA[Index of Suspicion in the Nursery: My Baby is Breathing Funny and Won't Eat]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/11/e564?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Posner, K. R.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Metabolic Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e564</dc:identifier>
<dc:title><![CDATA[Index of Suspicion in the Nursery: My Baby is Breathing Funny and Won't Eat]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e566</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e564</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/11/e567?rss=1">
<title><![CDATA[Strip of the Month: November 2009]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/11/e567?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Druzin, M. L., Peterson, N.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e567</dc:identifier>
<dc:title><![CDATA[Strip of the Month: November 2009]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e574</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e567</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/short/10/11/e575?rss=1">
<title><![CDATA[Visual Diagnosis: Skin Ulcerations in a Preterm Newborn (Click here)]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/short/10/11/e575?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Wambach, J., Morley, S. C.]]></dc:creator>
<dc:date>Mon, 02 Nov 2009 08:01:26 PST</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-11-e575</dc:identifier>
<dc:title><![CDATA[Visual Diagnosis: Skin Ulcerations in a Preterm Newborn (Click here)]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>11</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e575</prism:endingPage>
<prism:publicationDate>2009-11-01</prism:publicationDate>
<prism:startingPage>e575</prism:startingPage>
<prism:section>Visual Diagnosis</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/10/e479?rss=1">
<title><![CDATA[Neonatal Informatics Series]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/10/e479?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Philip, A. G.S.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:20 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e479</dc:identifier>
<dc:title><![CDATA[Neonatal Informatics Series]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e479</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e479</prism:startingPage>
<prism:section>Commentaries</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e480?rss=1">
<title><![CDATA[Neonatal Informatics--Dream of a Paperless NICU: Part One: The Emergence of Neonatal Informatics]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e480?rss=1</link>
<description><![CDATA[
<P>Attempts to "computerize neonatal intensive care units (NICUs)" emerged simultaneously with the development of neonatology, beginning in the 1960s. The academic underpinnings to inform prior computerization attempts awaited the birth of the newly emerging fields contained in "health-care informatics." Decades of attempts to computerize the NICU environment have produced local, partial successes, including successful installation of computerized monitors that report trends, buying or developing systems that produce letters from coded fact sheets, and development of many focused computer utilities to perform care task-related calculations.</P>
<P>Enormous political pressures are urging health care to "get computerized." Most hospitals are in the process of installing (or reinstalling) "hospital information systems (HISs)." Such efforts have exposed significant problems and limitations of current HIS systems for critical care situations. Extending office-designed computer systems safely and effectively into intensive care units and other real-time hospital venues has presented substantial difficulties. In late 2008, most NICUs still integrate multisource <I>clinical data at the bedside</I> by charting each hour with pen in small boxes on folding paper flowsheets, a slow, error-prone, and imprecise method for tracking unstable situations. To improve minute-by-minute management of unstable patients, all intensivists need automatic, real-time integration of machine, laboratory, and bedside observational data, presented in medically comprehensive, user-definable formats. Clinicians need reflex response speed (14 msec) in every clinical computer utility used in their "workflow." Similar sets of unique human computer/interactions of teams working in safety critical situations such as nuclear power plants, battleships, and airplane cockpits have been studied extensively by scientists known as "human factors engineers."</P>
<P>Human factors situations rarely have been studied in hospitals, and not at all for NICUs. Overall, this neonatal informatics series defines the current state of the "paperless" effort. Part 1 provides a historic and situational overview of current problems in optimizing hospital computer systems for critical clinicians, including communication, NICU computerization history, and an introduction to systems analysis, which is a key exercise for planning future NICU computer systems.</P>
]]></description>
<dc:creator><![CDATA[Drummond, W. H.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e480</dc:identifier>
<dc:title><![CDATA[Neonatal Informatics--Dream of a Paperless NICU: Part One: The Emergence of Neonatal Informatics]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e487</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e480</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e488?rss=1">
<title><![CDATA[Management of Micrognathia]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e488?rss=1</link>
<description><![CDATA[
<P>Micrognathia and the associated retroposition of the tongue into the oropharynx (glossoptosis) can obstruct the upper airway, producing obstructive apnea. The primary management of respiratory compromise in patients who have micrognathia is controversial. Numerous modalities have been used, including prone positioning, nasopharyngeal airways, tongue-lip adhesion, mandibular distraction, and tracheostomy. The goal of any intervention is to relieve airway obstruction, with secondary goals reported in the literature including avoidance or early removal of tracheostomy, improvement in feeding, and accelerated growth. This review examines nonsurgical and surgical therapeutic options and their outcomes. The diagnostic and treatment algorithm employed at the senior author's institution is presented.</P>
]]></description>
<dc:creator><![CDATA[Thimmappa, B., Hopkins, E., Schendel, S. A.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Respiratory Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e488</dc:identifier>
<dc:title><![CDATA[Management of Micrognathia]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e493</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e488</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e494?rss=1">
<title><![CDATA[Neonatal Vocal Cord Paralysis]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e494?rss=1</link>
<description><![CDATA[
<P>Neonatal vocal cord paralysis (VCP) remains an important cause of acute and chronic respiratory compromise in infants. Despite a normal cry, infants who have bilateral VCP may present with marked respiratory distress, and emergency tracheostomy is a lifesaving procedure in the most severe cases. Unilateral VCP usually causes more pronounced abnormalities of the infant's voice, but respiratory symptoms are typically mild. VCP most commonly results from iatrogenic causes due to injury to the left recurrent laryngeal nerve during cardiac surgery. VCP also can result from congenital or neurologic disorders. Vocal cord dysfunction usually improves over time but may take years to resolve. Infants who have VCP are at risk for aspiration, prolonged duration of mechanical ventilation, reactive airway disease, and persistent feeding problems. Serial examination of vocal cord function at regular intervals using flexible fiberoptic endoscopy or direct laryngoscopy is essential to monitor airway patency and document improvement or resolution of paralysis over time. Affected infants also must be followed closely to determine the need for future medical or surgical intervention.</P>
]]></description>
<dc:creator><![CDATA[Benjamin, J. R., Goldberg, R. N., Malcolm, W. F.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Respiratory Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e494</dc:identifier>
<dc:title><![CDATA[Neonatal Vocal Cord Paralysis]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e501</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e494</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e502?rss=1">
<title><![CDATA[Asymmetric Crying Facies]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/10/e502?rss=1</link>
<description><![CDATA[
<P>Asymmetric crying facies (ACF) refers to a neonate or infant whose face appears symmetric at rest and asymmetric during crying as the mouth is pulled downward on one side while not moving on the other side. It is a minor anomaly found in 1 per 160 live births and is caused by hypoplasia or agenesis of the depressor anguli oris muscle (DAOM) or compression of one of the branches of the facial nerve. Associated major and minor malformations as well as deformations have been described. The risk of associated major anomalies with ACF is 3.5-fold higher compared with the general population. Such anomalies are most common in the cardiovascular system and cervicofacial region. Certain clinical signs may differentiate ACF from true facial paralysis. Physical findings, electromyography, and ultrasonography studies can help differentiate between the two causes of ACF. An approach to the diagnostic evaluation is suggested, both for initial evaluation and for decisions about subsequent treatment of ACF.</P>
]]></description>
<dc:creator><![CDATA[Shapira, M., Borochowitz, Z. U.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Genetics/Dysmorphology]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e502</dc:identifier>
<dc:title><![CDATA[Asymmetric Crying Facies]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e509</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e502</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/10/e510?rss=1">
<title><![CDATA[Index of Suspicion in the Nursery]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/10/e510?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Smith, H., Vachharajani, A.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Genetics/Dysmorphology]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e510</dc:identifier>
<dc:title><![CDATA[Index of Suspicion in the Nursery]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e511</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e510</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/10/e512?rss=1">
<title><![CDATA[Strip of the Month: October 2009]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/10/e512?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Druzin, M. L., Arafeh, J. M.R.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e512</dc:identifier>
<dc:title><![CDATA[Strip of the Month: October 2009]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e518</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e512</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/short/10/10/e519?rss=1">
<title><![CDATA[Visual Diagnosis: Cheek Redness in a Newborn (Click here)]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/short/10/10/e519?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Kitcharoensakkul, M., Najaf, T. A.]]></dc:creator>
<dc:date>Thu, 01 Oct 2009 08:01:21 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-10-e519</dc:identifier>
<dc:title><![CDATA[Visual Diagnosis: Cheek Redness in a Newborn (Click here)]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>10</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e519</prism:endingPage>
<prism:publicationDate>2009-10-01</prism:publicationDate>
<prism:startingPage>e519</prism:startingPage>
<prism:section>Visual Diagnosis</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/9/e431?rss=1">
<title><![CDATA[Educational Perspectives: Modeling Expertise in Medical Education]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/9/e431?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Leonard, D. T., Anderson, J. M.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e431</dc:identifier>
<dc:title><![CDATA[Educational Perspectives: Modeling Expertise in Medical Education]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e434</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e431</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/9/e435?rss=1">
<title><![CDATA[Thrombocytopenia in the Neonatal Intensive Care Unit]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/9/e435?rss=1</link>
<description><![CDATA[
<P>As the survival of neonates cared for in the neonatal intensive care unit (NICU) has improved, hematologic issues have been recognized as clinically significant problems in this population. Thrombocytopenia, in particular, is a common finding among sick neonates, but there is considerable debate regarding the appropriate evaluation and management of affected infants. This article provides state-of-the art information on the pathophysiology, diagnosis, and treatment of neonatal thrombocytopenia. Specifically, the risks associated with low platelet counts in neonates are discussed, and a practical approach to the differential diagnosis of neonates who develop thrombocytopenia is provided. Current recommendations for the management of immune and nonimmune varieties of thrombocytopenia also are reviewed, with an emphasis on the risks and benefits associated with platelet transfusions in this age group.</P>
]]></description>
<dc:creator><![CDATA[Saxonhouse, M. A., Sola-Visner, M. C.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Disorders of Blood/Neoplasms]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e435</dc:identifier>
<dc:title><![CDATA[Thrombocytopenia in the Neonatal Intensive Care Unit]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e445</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e435</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/9/e446?rss=1">
<title><![CDATA[Immune-mediated Neutropenia in the Neonate]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/9/e446?rss=1</link>
<description><![CDATA[
<P>Neutropenia is a relatively common finding in ill neonates, occurring in approximately 32,000 infants each year in the United States. In this patient population, immune-mediated neutropenia results from the antibody-mediated destruction of neutrophils and is associated with such disorders as alloimmune neonatal neutropenia, neonatal autoimmune neutropenia, and autoimmune neutropenia of infancy. Such conditions only recently have begun to be understood and often are problematic in terms of clinical identification and laboratory confirmation. This article reviews the clinical presentation, laboratory diagnosis, and treatment options for these three disorders.</P>
]]></description>
<dc:creator><![CDATA[Black, L. V., Maheshwari, A.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Disorders of Blood/Neoplasms]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e446</dc:identifier>
<dc:title><![CDATA[Immune-mediated Neutropenia in the Neonate]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e453</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e446</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/9/e454?rss=1">
<title><![CDATA[Preeclampsia and Neonatal Neutropenia]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/9/e454?rss=1</link>
<description><![CDATA[
<P>Neutropenia is a common hematologic disorder in the newborn intensive care unit, particularly in preterm neonates. Although its cause varies, a significant proportion of the episodes are associated with pregnancy complicated by preeclampsia. In this review, we provide a brief overview of preeclampsia and neonatal neutropenia, with a focus on the neonatal neutropenia associated with maternal preeclampsia. We discuss potential contributory mechanisms to and the natural history of this type of neutropenia, as well as reasonable management strategies in affected neonates.</P>
]]></description>
<dc:creator><![CDATA[Moallem, M., Koenig, J. M.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Disorders of Blood/Neoplasms]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e454</dc:identifier>
<dc:title><![CDATA[Preeclampsia and Neonatal Neutropenia]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e459</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e454</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/9/e460?rss=1">
<title><![CDATA[Index of Suspicion in the Nursery]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/9/e460?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Arevalo, A., Wetzel, G. T., Cabrera, A. G.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Cardiovascular Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e460</dc:identifier>
<dc:title><![CDATA[Index of Suspicion in the Nursery]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e462</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e460</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/9/e463?rss=1">
<title><![CDATA[Strip of the Month: September 2009]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/9/e463?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Druzin, M. L., Peterson, N.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e463</dc:identifier>
<dc:title><![CDATA[Strip of the Month: September 2009]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e470</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e463</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/short/10/9/e471?rss=1">
<title><![CDATA[Visual Diagnosis: Respiratory Distress and Feeding Intolerance in a 3-day-old Newborn (Click here)]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/short/10/9/e471?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Wegner, J. L., Anderson, J. M.]]></dc:creator>
<dc:date>Tue, 01 Sep 2009 08:01:23 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-9-e471</dc:identifier>
<dc:title><![CDATA[Visual Diagnosis: Respiratory Distress and Feeding Intolerance in a 3-day-old Newborn (Click here)]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>9</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e471</prism:endingPage>
<prism:publicationDate>2009-09-01</prism:publicationDate>
<prism:startingPage>e471</prism:startingPage>
<prism:section>Visual Diagnosis</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e381?rss=1">
<title><![CDATA[International Perspectives: Late-onset Circulatory Collapse in Very Low-birthweight Infants: A Japanese Perspective]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e381?rss=1</link>
<description><![CDATA[
<P>The number of reports of sudden deterioration in blood pressure with concomitant decrease of urine output among extremely low-birthweight (ELBW) infants whose general condition is stable have increased recently in Japan. This disorder is clearly different from an unstable circulatory status during the acute phase soon after delivery. The disorder usually occurs more than 1 week after birth, when the infant's circulatory status already is stable. Blood pressure in such hypotensive infants cannot be restored with volume expanders or inotropic agents; it only improves with glucocorticoid administration. The efficacy of steroids in preterm infants who develop hypotension soon after birth is widely known, but the time of onset of this paroxysmal hypotension is apparently different. Relative adrenal insufficiency is considered to be the primary cause of this late-onset hypotension, but the pathogenesis has not been elucidated definitively. The disease is diagnosed clinically and by exclusion. When hypotension persists, it may aggravate chronic lung disease (CLD) and cause periventricular leukomalacia (PVL), which emphasizes the importance of early diagnosis and treatment.</P>
]]></description>
<dc:creator><![CDATA[Miwa, M., Kusuda, S., Ikeda, K.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:11 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Critical Care, Cardiovascular Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e381</dc:identifier>
<dc:title><![CDATA[International Perspectives: Late-onset Circulatory Collapse in Very Low-birthweight Infants: A Japanese Perspective]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e386</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e381</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e387?rss=1">
<title><![CDATA[Epigenetics and Neonatology: The Birth of a New Era]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e387?rss=1</link>
<description><![CDATA[
<P>Although an individual's cells all have the same DNA, each cell type has a different pattern of active (expressed) and inactive genes. Such patterns are established or programmed during development by epigenetic modifications involving small molecules that covalently bind to specific sites in DNA or DNA-packaging proteins. The modifications regulate gene activity without changing the DNA sequence. Diet, lifestyle factors, and exposure to toxins or other adverse factors as well as random epigenetic mutations can result in de novo epigenetic modifications that may influence the course of development. The perinatal period is a time of rapid physiologic change during which some epigenetic reprogramming is likely to occur. Further, adverse events at this time may lead to epigenetic changes that have implications for future health and well-being. Evidence suggests that epigenetics plays a part in mediating effects of the perinatal environment and that such epigenetic changes may be reversed later in life. This has major implications for understanding of the cause of preterm birth as well as the consequences of prematurity.</P>
]]></description>
<dc:creator><![CDATA[Morley, R., Saffery, R., Hacking, D. F., Craig, J. M.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:11 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Genetics/Dysmorphology]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e387</dc:identifier>
<dc:title><![CDATA[Epigenetics and Neonatology: The Birth of a New Era]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e395</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e387</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e396?rss=1">
<title><![CDATA[Treatment of Latent Tuberculosis Infection]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e396?rss=1</link>
<description><![CDATA[
<P>Latent tuberculosis infection (LTBI) is the most common source for active tuberculosis (TB), and its treatment remains an important cornerstone of global TB eradication. Although pregnancy may represent a unique time during which LTBI may be treated successfully, pregnancy and the postpartum period have been recognized as periods during which the risk of hepatitis from isoniazid (INH), the drug of choice for LTBI, may be increased. Thus, recommendations have suggested postponing treatment of LTBI until the postpartum period. Recent programs indicate that in properly designed surveillance programs, the risk of INH-induced hepatitis is low. Similar to other ongoing clinical encounters in which targeted LTBI screening and treatment may be accomplished, such as methadone and needle exchange clinics, antenatal clinics represent an opportunity to establish trust between clinician and patient for ongoing surveillance for complications and compliance. Furthermore, the addition of a newborn into the household where LTBI has been found poses new implications for eradication of TB. Prospective data collection on outcomes for such programs will be invaluable in assessing the efficacy of these efforts.</P>
]]></description>
<dc:creator><![CDATA[Kessler, M., Smith, J. F.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:11 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Infectious Diseases, Respiratory Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e396</dc:identifier>
<dc:title><![CDATA[Treatment of Latent Tuberculosis Infection]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e401</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e396</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e402?rss=1">
<title><![CDATA[Metabolic Bone Disease of Prematurity]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/abstract/10/8/e402?rss=1</link>
<description><![CDATA[
<P>The incidence of metabolic bone disease (MBD) in preterm infants has been declining due to advances in nutritional care. Although the terms osteopenia and rickets have been used in the literature, MBD of prematurity is the preferred terminology for this condition. Despite the use of human milk fortifiers and commercial infant formulas specified for this population, MBD remains an important cause of morbidity in preterm infants. This review focuses on the physiology of intrauterine bone growth, the development of MBD in preterm infants, the various risk factors for MBD, pitfalls in diagnosis, prevention, and treatment of MBD. The use of speed of sound (SOS) ultrasonography and dual-energy X-ray absorptiometry (DXA) in the diagnosis, management, and prognosis also is discussed.</P>
]]></description>
<dc:creator><![CDATA[Vachharajani, A. J., Mathur, A. M., Rao, R.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:11 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Musculoskeletal Disorders, Metabolic Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e402</dc:identifier>
<dc:title><![CDATA[Metabolic Bone Disease of Prematurity]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e411</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e402</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/8/e412?rss=1">
<title><![CDATA[Index of Suspicion in the Nursery]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/8/e412?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Podraza, J.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:11 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant, Endocrine Disorders]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e412</dc:identifier>
<dc:title><![CDATA[Index of Suspicion in the Nursery]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e414</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e412</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/full/10/8/e415?rss=1">
<title><![CDATA[Strip of the Month: August 2009]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/full/10/8/e415?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Druzin, M. L., Arafeh, J. M.R.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:12 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e415</dc:identifier>
<dc:title><![CDATA[Strip of the Month: August 2009]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e422</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e415</prism:startingPage>
<prism:section>Articles</prism:section>
</item>

<item rdf:about="http://neoreviews.aappublications.org/cgi/content/short/10/8/e423?rss=1">
<title><![CDATA[Visual Diagnosis: Elevated Right Hemi-diaphragm in a Newborn (Click here)]]></title>
<link>http://neoreviews.aappublications.org/cgi/content/short/10/8/e423?rss=1</link>
<description><![CDATA[]]></description>
<dc:creator><![CDATA[Vachharajani, A., Keswani, S. G., Warner, B. W.]]></dc:creator>
<dc:date>Fri, 31 Jul 2009 08:01:12 PDT</dc:date>
<dc:subject><![CDATA[Fetus and Newborn Infant]]></dc:subject>
<dc:identifier>info:doi/10.1542/neo.10-8-e423</dc:identifier>
<dc:title><![CDATA[Visual Diagnosis: Elevated Right Hemi-diaphragm in a Newborn (Click here)]]></dc:title>
<dc:publisher>American Academy of Pediatrics</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>10</prism:volume>
<prism:endingPage>e423</prism:endingPage>
<prism:publicationDate>2009-08-01</prism:publicationDate>
<prism:startingPage>e423</prism:startingPage>
<prism:section>Visual Diagnosis</prism:section>
</item>

</rdf:RDF>