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American Academy of Pediatrics
Article

Perinatal Nutrition, Epigenetics, and Disease

Lisa A. Joss-Moore and Robert H. Lane
NeoReviews September 2011, 12 (9) e498-e505; DOI: https://doi.org/10.1542/neo.12-9-e498
Lisa A. Joss-Moore
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Robert H. Lane
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Abstract

Nutrition and growth during the perinatal period have long-term implications for neonates. The Developmental Origins of Disease Hypothesis states that molecular and cellular events initiated during this period have the potential to impart lifelong phenotypic changes to infants. Undernutrition resulting in intra- or extrauterine growth restriction is associated with an increased risk of neurodevelopmental impairment and lung disease as well as adult-onset diseases, including obesity, insulin resistance, and cardiovascular disease. A proposed molecular mechanism by which early events alter later health is epigenetic modifications to chromatin. One well-studied epigenetic modifier is nutrition. Much of the current evidence associating early nutritional status to epigenetic adaptations stems from animal models. This review summarizes known associations between perinatal nutrition and epigenetic alterations to chromatin. Much work remains in the field to identify how associated histone and DNA modifications contribute to changes in gene expression. It also is important to determine why a particular gene is targeted in the first place. Detailed understanding of these aspects of perinatal nutrition and epigenetics should allow development of specific, targeted interventions.

  • Copyright © 2011 by the American Academy of Pediatrics

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NeoReviews
Vol. 12, Issue 9
1 Sep 2011
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Perinatal Nutrition, Epigenetics, and Disease
Lisa A. Joss-Moore, Robert H. Lane
NeoReviews Sep 2011, 12 (9) e498-e505; DOI: 10.1542/neo.12-9-e498

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Perinatal Nutrition, Epigenetics, and Disease
Lisa A. Joss-Moore, Robert H. Lane
NeoReviews Sep 2011, 12 (9) e498-e505; DOI: 10.1542/neo.12-9-e498
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  • Article
    • Abstract
    • Objectives
    • Introduction
    • Nutrition and the Developmental Origins of Disease
    • The Nuts and Bolts of Epigenetics
    • Epigenetics as a Mechanism for Developmental Origins
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