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American Academy of Pediatrics
Article

Antibiotic Therapy and Early Onset Sepsis

Gustave Falciglia, Joseph R. Hageman, Michael Schreiber and Kenneth Alexander
NeoReviews February 2012, 13 (2) e86-e93; DOI: https://doi.org/10.1542/neo.13-2-e86
Gustave Falciglia
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Joseph R. Hageman
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Michael Schreiber
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Kenneth Alexander
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Abstract

Early onset sepsis in the newborn infant continues to be an important clinical problem for neonatologists everywhere in the world. Different routes of transmission, changes in causative agents, and potential antibiotic resistance all influence the choice of antibiotic therapy. Group B Streptococcus and Escherichia coli continue to be the major pathogens dictating antibiotic therapy in the United States. Ampicillin and gentamicin are the antibiotics used by most for empirical therapy; cephalosporins are used in certain clinical situations. In this review, we address the reasons for these choices while highlighting clinically relevant aspects of the antibiotics commonly used in the treatment of early onset sepsis in the newborn.

  • Abbreviations:
    EOS;
    early onset sepsis
    ESBL;
    extended spectrum β lactamase
    GBS;
    group B Streptococcus
    IAP;
    intrapartum antibiotic prophylaxis
    PBP;
    penicillin-binding protein
    VLBW;
    very low birth weight
    • © American Academy of Pediatrics, 2012. All rights reserved.

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    In this issue

    NeoReviews
    Vol. 13, Issue 2
    1 Feb 2012
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    Antibiotic Therapy and Early Onset Sepsis
    Gustave Falciglia, Joseph R. Hageman, Michael Schreiber, Kenneth Alexander
    NeoReviews Feb 2012, 13 (2) e86-e93; DOI: 10.1542/neo.13-2-e86

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    Antibiotic Therapy and Early Onset Sepsis
    Gustave Falciglia, Joseph R. Hageman, Michael Schreiber, Kenneth Alexander
    NeoReviews Feb 2012, 13 (2) e86-e93; DOI: 10.1542/neo.13-2-e86
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    • Article
      • Abstract
      • Educational Gaps
      • Objectives
      • Introduction
      • EOS: Definitions and Causative Agents
      • Effects of Intrapartum Antibiotic Prophylaxis
      • Empirical Versus Definitive Therapy of EOS
      • Criteria for Change
      • Footnotes
      • References
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