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American Academy of Pediatrics
Article

Neonatal Thrombocytopenia

Karen S. Fernández and Pedro de Alarcón
NeoReviews February 2013, 14 (2) e74-e82; DOI: https://doi.org/10.1542/neo.14-2-e74
Karen S. Fernández
*Assistant Professor of Pediatrics, University of Illinois College of Medicine at Peoria and Children’s Hospital of Illinois, Peoria, IL.
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Pedro de Alarcón
†William H. Albers Professor and Chair Department of Pediatrics, University of Illinois College of Medicine at Peoria and Children’s Hospital of Illinois, Peoria, IL.
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Abstract

Thrombocytopenia is one of the most common hematologic problems in the neonate. It affects up to 30% of all patients admitted to the neonatal intensive care unit (NICU). The causes of thrombocytopenia in neonates are diverse and include immune, inherited, and acquired disorders. The evaluation of the neonate with thrombocytopenia may be challenging. Developing a diagnostic strategy to evaluate the neonate with thrombocytopenia is key for the practicing clinician. Here, we provide a practical approach to the evaluation of the neonate with thrombocytopenia and an overview of its most common etiologies.

  • Abbreviations:
    BSS;
    Bernard Soulier syndrome
    CAMT;
    congenital amegakaryocytic thrombocytopenia
    DIC;
    disseminated intravascular coagulation
    FA;
    Fanconi anemia
    GP;
    glycoprotein
    HPA;
    human platelet antigen
    ICH;
    intracranial hemorrhage
    IVIG;
    intravenous immunoglobulin
    NAIT;
    neonatal alloimmune thrombocytopenia
    NEC;
    necrotizing enterocolitis
    NICU;
    neonatal intensive care unit
    TAR;
    thrombocytopenia absent radii
    Tpo;
    thrombopoietin
    WAS;
    Wiskott-Aldrich syndrome
    • Copyright © 2013 by the American Academy of Pediatrics

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    In this issue

    NeoReviews
    Vol. 14, Issue 2
    1 Feb 2013
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    Neonatal Thrombocytopenia
    Karen S. Fernández, Pedro de Alarcón
    NeoReviews Feb 2013, 14 (2) e74-e82; DOI: 10.1542/neo.14-2-e74

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    Neonatal Thrombocytopenia
    Karen S. Fernández, Pedro de Alarcón
    NeoReviews Feb 2013, 14 (2) e74-e82; DOI: 10.1542/neo.14-2-e74
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    • Article
      • Abstract
      • Educational Gaps
      • Objectives
      • Definition and Incidence
      • Platelets Production in the Newborn
      • Platelet Count and Risk of Bleeding
      • Diagnostic Approach to Neonatal Thrombocytopenia
      • Immune-Mediated Causes of Neonatal Thrombocytopenia
      • Inherited Thrombocytopenias
      • Consumptive Causes of Thrombocytopenia in the Neonatal Period
      • Conclusions
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    • Update on the Use of Intravenous Immunoglobulin in Pregnancy
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