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Abstract
Thrombocytopenia is one of the most common hematologic problems in the neonate. It affects up to 30% of all patients admitted to the neonatal intensive care unit (NICU). The causes of thrombocytopenia in neonates are diverse and include immune, inherited, and acquired disorders. The evaluation of the neonate with thrombocytopenia may be challenging. Developing a diagnostic strategy to evaluate the neonate with thrombocytopenia is key for the practicing clinician. Here, we provide a practical approach to the evaluation of the neonate with thrombocytopenia and an overview of its most common etiologies.
- BSS;
- Bernard Soulier syndrome
- CAMT;
- congenital amegakaryocytic thrombocytopenia
- DIC;
- disseminated intravascular coagulation
- FA;
- Fanconi anemia
- GP;
- glycoprotein
- HPA;
- human platelet antigen
- ICH;
- intracranial hemorrhage
- IVIG;
- intravenous immunoglobulin
- NAIT;
- neonatal alloimmune thrombocytopenia
- NEC;
- necrotizing enterocolitis
- NICU;
- neonatal intensive care unit
- TAR;
- thrombocytopenia absent radii
- Tpo;
- thrombopoietin
- WAS;
- Wiskott-Aldrich syndrome
- Copyright © 2013 by the American Academy of Pediatrics
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- Article
- Abstract
- Educational Gaps
- Objectives
- Definition and Incidence
- Platelets Production in the Newborn
- Platelet Count and Risk of Bleeding
- Diagnostic Approach to Neonatal Thrombocytopenia
- Immune-Mediated Causes of Neonatal Thrombocytopenia
- Inherited Thrombocytopenias
- Consumptive Causes of Thrombocytopenia in the Neonatal Period
- Conclusions
- Footnotes
- Suggested Reading
- Figures & Data
- Info & Metrics
- Comments
- Quiz