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- C5a,
- anaphylatoxin
- CRP,
- C-reactive protein
- EGF,
- epidermal growth factor
- FC,
- fecal calprotectin
- I-FABP,
- urinary intestinal fatty acid–binding protein
- IaIp,
- inter-α-inhibitory protein
- NEC,
- necrotizing enterocolitis
- PAF,
- platelet-activating factor
- SAA,
- serum amyloid A
- TLR,
- toll-like receptor
- TPN,
- total parenteral nutrition
Abstract
Necrotizing enterocolitis (NEC) is an inflammatory disease of the intestine that largely affects very low birthweight premature infants. It is a disease process that can be widely variable in its course and outcomes. Because the etiology and pathogenesis of NEC still remain incompletely understood, treatment options and morbidity and mortality for infants who have NEC have not significantly improved in the past four decades. Given the potentially devastating outcomes of NEC, it is imperative to focus research efforts on potential markers that could identify this disease process early in its course, as well as predict the course and severity of disease to improve outcomes. Perhaps more importantly, this article reviews the current status of preventive measures for NEC.
- Copyright © 2013 by the American Academy of Pediatrics
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