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American Academy of Pediatrics
Article

Necrotizing Enterocolitis

Predictive Markers and Preventive Strategies

Alison Chu, Joseph R. Hageman and Michael S. Caplan
NeoReviews March 2013, 14 (3) e113-e120; DOI: https://doi.org/10.1542/neo.14-3-e113
Alison Chu
*Fellow in Neonatology, Pritzker School of Medicine, University of Chicago, Chicago, IL.
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Joseph R. Hageman
†NorthShore University Health System, Department of Pediatrics, Evanston, IL, and Professor Emeritus of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL.
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Michael S. Caplan
‡Chairman, Department of Pediatrics, NorthShore University HealthSystem, and Clinical Professor of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL.
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  • Abbreviations:
    C5a,
    anaphylatoxin
    CRP,
    C-reactive protein
    EGF,
    epidermal growth factor
    FC,
    fecal calprotectin
    I-FABP,
    urinary intestinal fatty acid–binding protein
    IaIp,
    inter-α-inhibitory protein
    NEC,
    necrotizing enterocolitis
    PAF,
    platelet-activating factor
    SAA,
    serum amyloid A
    TLR,
    toll-like receptor
    TPN,
    total parenteral nutrition
  • Abstract

    Necrotizing enterocolitis (NEC) is an inflammatory disease of the intestine that largely affects very low birthweight premature infants. It is a disease process that can be widely variable in its course and outcomes. Because the etiology and pathogenesis of NEC still remain incompletely understood, treatment options and morbidity and mortality for infants who have NEC have not significantly improved in the past four decades. Given the potentially devastating outcomes of NEC, it is imperative to focus research efforts on potential markers that could identify this disease process early in its course, as well as predict the course and severity of disease to improve outcomes. Perhaps more importantly, this article reviews the current status of preventive measures for NEC.

    • Copyright © 2013 by the American Academy of Pediatrics

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    NeoReviews
    Vol. 14, Issue 3
    1 Mar 2013
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    Necrotizing Enterocolitis
    Alison Chu, Joseph R. Hageman, Michael S. Caplan
    NeoReviews Mar 2013, 14 (3) e113-e120; DOI: 10.1542/neo.14-3-e113

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    Necrotizing Enterocolitis
    Alison Chu, Joseph R. Hageman, Michael S. Caplan
    NeoReviews Mar 2013, 14 (3) e113-e120; DOI: 10.1542/neo.14-3-e113
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