Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors
    • Author Guidelines
  • Content
    • Current Issue
    • Complete Issue PDF
    • Archive
    • 20th Anniversary Special Edition
    • Topic/Program Collections
    • Blog
    • Questions from NeoReviews
  • CME/MOC
    • CME Quizzes
    • MOC Claiming
    • NeoReviewsPlus
    • Board Review Study Guide
  • Multimedia
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors
    • Author Guidelines
  • Content
    • Current Issue
    • Complete Issue PDF
    • Archive
    • 20th Anniversary Special Edition
    • Topic/Program Collections
    • Blog
    • Questions from NeoReviews
  • CME/MOC
    • CME Quizzes
    • MOC Claiming
    • NeoReviewsPlus
    • Board Review Study Guide
  • Multimedia
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
American Academy of Pediatrics
Article

The Many Faces of B Cells

From Generation of Antibodies to Immune Regulation

Robert L. Schelonka and Akhil Maheshwari
NeoReviews September 2013, 14 (9) e438-e447; DOI: https://doi.org/10.1542/neo.14-9-e438
Robert L. Schelonka
*Associate Professor of Pediatrics, Oregon Health & Science University, Portland, OR.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akhil Maheshwari
†Associate Professor of Pediatrics, University of Illinois, Chicago, IL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Comments
  • Quiz
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Download PDF

Abstract

B lineage lymphocytes (B cells) produce exquisitely specific and long-lasting antibodies that recognize a broad and ever-changing array of foreign antigens and microbial pathogens. Perturbations in B-cell development maturation lead to specific immune disturbances. Certain features intrinsic to fetal and neonatal B cells contribute to what has been called the relative immunodeficiency of infancy. Although the primary function of B lineage cells is to produce antibodies for host defense, emerging data show that B cells are key activators and regulators of the immune response.

  • Abbreviations:
    BCR;
    B-cell antigen receptor
    CDR-H3;
    third complementarity-determining region
    DC;
    dendritic cell
    MZ;
    marginal zone
    sIgM;
    surface immunoglobulin M
    TdT;
    terminal deoxynucleotidyl transferase
    • Copyright © 2013 by the American Academy of Pediatrics

    Individual Login

    Log in
    You will be redirected to aap.org to login or to create your account.

    Institutional Login

    via Institution

    You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.

    Log in through your institution

    If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

    Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00

    Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

    Offer Reprints

    PreviousNext
    Back to top

    Advertising Disclaimer »

    In this issue

    NeoReviews
    Vol. 14, Issue 9
    1 Sep 2013
    • Table of Contents
    • Table of Contents (PDF)
    • Index by author
    • Complete Issue (PDF)
    View this article with LENS
    PreviousNext
    Email Article

    Thank you for your interest in spreading the word on American Academy of Pediatrics.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    The Many Faces of B Cells
    (Your Name) has sent you a message from American Academy of Pediatrics
    (Your Name) thought you would like to see the American Academy of Pediatrics web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Request Permissions
    Article Alerts
    Log in
    You will be redirected to aap.org to login or to create your account.
    Or Sign In to Email Alerts with your Email Address
    Citation Tools
    The Many Faces of B Cells
    Robert L. Schelonka, Akhil Maheshwari
    NeoReviews Sep 2013, 14 (9) e438-e447; DOI: 10.1542/neo.14-9-e438

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Quiz
    Share
    The Many Faces of B Cells
    Robert L. Schelonka, Akhil Maheshwari
    NeoReviews Sep 2013, 14 (9) e438-e447; DOI: 10.1542/neo.14-9-e438
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    Print
    Download PDF
    Insight Alerts
    • Table of Contents

    Jump to section

    • Article
      • Abstract
      • Educational Gaps
      • Objectives
      • Overview of B Cells in Adaptive Immunity
      • What Characterizes B Cells?
      • How Do B Cells Develop?
      • What Happens When B-Cell Development Goes Awry?
      • Development of the B-Cell Receptor Repertoire
      • Immunoglobulin Repertoire
      • Serum Immunoglobulin Concentrations
      • Fetal and Neonatal Adaptive Immune Function
      • Practical Implications of an Immature Immune Response
      • B-Cell Functions in Addition to Antibody Production
      • What Are the Roles of Other B-Cell Subpopulations?
      • Summary
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • Comments
    • Quiz

    Related Articles

    • Google Scholar

    Cited By...

    • No citing articles found.
    • Google Scholar

    More in this TOC Section

    • Protection of the Newborn Through Vaccination in Pregnancy
    • Update on the Use of Intravenous Immunoglobulin in Pregnancy
    • Advancing Health Equity by Translating Lessons Learned from NICU Family Visitations During the COVID-19 Pandemic
    Show more Article

    Similar Articles

    Subjects

    • Medical Education
      • Journal CME
    • Fetus/Newborn Infant
      • Neonatology
    • Allergy/Immunology
      • Allergy/Immunology
    • Journal Info
    • Editorial Board
    • Overview
    • Licensing Information
    • Authors/Reviewers
    • Author Guidelines
    • Submit My Manuscript
    • Librarians
    • Institutional Subscriptions
    • Usage Stats
    • Support
    • Contact Us
    • Subscribe
    • Resources
    • Media Kit
    • About
    • NeoReviewsPlus
    • International Access
    • Terms of Use
    • Privacy Statement
    • FAQ
    • AAP.org
    • shopAAP
    • Follow American Academy of Pediatrics on Instagram
    • Visit American Academy of Pediatrics on Facebook
    • Follow American Academy of Pediatrics on Twitter
    • Follow American Academy of Pediatrics on Youtube
    • RSS
    • NeoReviews® and NeoReviewsPlus™ are supported, in part, through an educational grant from Abbott Nutrition, a division of Abbott Laboratories, Inc.
    American Academy of Pediatrics

    © 2021 American Academy of Pediatrics