This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Abstract
The immune system has evolved to fend off challenges from a wide array of pathogens while maintaining tolerance to self-antigens and benign environmental antigens. CD4 helper T cells are critical in regulating these processes with different subsets of CD4 T cells responsible for regulating different facets of the immune system. T helper 1 (Th1) cells, which contribute to antiviral immunity, and T helper 2 (Th2) cells, which contribute to antihelminth immunity and allergy, were the first CD4 T cell subsets to be discovered. Recently a number of new subsets have been discovered. Here we review what is known about CD4 T cell subsets with particular focus on neonatal immunity.
- CMV;
- cytomegalovirus
- HSV;
- herpes simplex virus
- IFN;
- interferon
- Ig;
- immunoglobulin
- IL;
- interleukin
- iTreg;
- induced regulatory T cell
- MHC;
- major histocompatibility complex
- NK;
- natural killer
- PTK7;
- protein tyrosine kinase 7
- RTE;
- recent thymic emigrant
- STAT;
- signal transducer and activator of transcription
- TCR;
- T cell receptor
- Th;
- T helper
- Treg;
- regulatory T cell
- Copyright © 2013 by the American Academy of Pediatrics
Individual Login
Institutional Login
You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.
Log in through your institution
Purchase access
In this issue
Jump to section
- Article
- Abstract
- Educational Gaps
- Objectives
- Introduction
- CD4 T Cell Life Cycle Overview
- CD4 T Helper Subset Differentiation: General Principles
- Memory Versus Naïve
- Neonatal Naïve T Cells Versus Adult Naïve T Cells
- Th1 and Th2 Cells
- Regulatory T Cells
- Th17 Cells
- Other Emerging T Cell Subsets
- Future Directions
- Conclusions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- Comments
Related Articles
Cited By...
- No citing articles found.