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Abstract
The immune system has evolved to fend off challenges from a wide array of pathogens while maintaining tolerance to self-antigens and benign environmental antigens. CD4 helper T cells are critical in regulating these processes with different subsets of CD4 T cells responsible for regulating different facets of the immune system. T helper 1 (Th1) cells, which contribute to antiviral immunity, and T helper 2 (Th2) cells, which contribute to antihelminth immunity and allergy, were the first CD4 T cell subsets to be discovered. Recently a number of new subsets have been discovered. Here we review what is known about CD4 T cell subsets with particular focus on neonatal immunity.
- CMV;
- cytomegalovirus
- HSV;
- herpes simplex virus
- IFN;
- interferon
- Ig;
- immunoglobulin
- IL;
- interleukin
- iTreg;
- induced regulatory T cell
- MHC;
- major histocompatibility complex
- NK;
- natural killer
- PTK7;
- protein tyrosine kinase 7
- RTE;
- recent thymic emigrant
- STAT;
- signal transducer and activator of transcription
- TCR;
- T cell receptor
- Th;
- T helper
- Treg;
- regulatory T cell
- Copyright © 2013 by the American Academy of Pediatrics
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In this issue
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- Article
- Abstract
- Educational Gaps
- Objectives
- Introduction
- CD4 T Cell Life Cycle Overview
- CD4 T Helper Subset Differentiation: General Principles
- Memory Versus Naïve
- Neonatal Naïve T Cells Versus Adult Naïve T Cells
- Th1 and Th2 Cells
- Regulatory T Cells
- Th17 Cells
- Other Emerging T Cell Subsets
- Future Directions
- Conclusions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- Comments
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