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American Academy of Pediatrics
Article

Neonatal Antiphospholipid Syndrome

Claudia Saad Magalhães, Ligia Maria Suppo de Souza Rugolo and Cleide Enoir Petean Trindade
NeoReviews May 2014, 15 (5) e169-e176; DOI: https://doi.org/10.1542/neo.15-5-e169
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Claudia Saad Magalhães
*Department of Pediatrics, Pediatric Rheumatology Unit, Botucatu Medical School, Sao Paulo State University, Brazil.
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Ligia Maria Suppo de Souza Rugolo
†Department of Pediatrics, Neonatology Unit, Botucatu Medical School, Sao Paulo State University, Brazil.
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Cleide Enoir Petean Trindade
†Department of Pediatrics, Neonatology Unit, Botucatu Medical School, Sao Paulo State University, Brazil.
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  • Abbreviations:
    AID,
    autoimmune diseases
    APS,
    antiphospholipid antibody syndrome
    aPLs,
    antiphospholipid antibodies
    aCLs,
    anticardiolipin antibodies
    CAPS,
    catastrophic antiphospholipid antibody syndrome
    GP-I,
    anti-β-2 glycoprotein I antibodies
    HLA,
    histocompatibility leukocyte antigen
    Ig,
    immunoglobulin
    LA,
    lupus anticoagulant
    SLE,
    systemic lupus erythematosus
  • Abstract

    Antiphospholipid antibody syndrome (APS) during pregnancy may result in pregnancy morbidity and passive transfer of antibodies to the fetus, resulting in an increased risk of prematurity, intrauterine growth restriction, thrombocytopenia, and developmental delay. Antiphospholipid antibodies may have an impact on neurodevelopment during fetal life. Although rare, persistence of these antibodies in the neonate may lead to thromboembolism, particularly if there is a concurrent infection and/or inherited thrombophilic disorders. Affected pregnant women need to be identified early during gestation so that they can have close monitoring of the placental circulation, fetal growth and development, and testing of serum antiphospholipid antibody levels. Neonates born to mothers with antiphospholipid antibody syndrome should have close neurodevelopment follow-up.

    • Copyright © 2014 by the American Academy of Pediatrics

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    NeoReviews
    Vol. 15, Issue 5
    1 May 2014
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    Neonatal Antiphospholipid Syndrome
    Claudia Saad Magalhães, Ligia Maria Suppo de Souza Rugolo, Cleide Enoir Petean Trindade
    NeoReviews May 2014, 15 (5) e169-e176; DOI: 10.1542/neo.15-5-e169

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    Neonatal Antiphospholipid Syndrome
    Claudia Saad Magalhães, Ligia Maria Suppo de Souza Rugolo, Cleide Enoir Petean Trindade
    NeoReviews May 2014, 15 (5) e169-e176; DOI: 10.1542/neo.15-5-e169
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    • Article
      • Abstract
      • Educational Gaps
      • Objectives
      • Definition of Antiphospholipid Antibody Syndrome
      • Passive Transfer of Antiphospholipid Antibodies and Neonatal Morbidity
      • Neonatal Thrombosis
      • Pregnancy Morbidity
      • Conclusions
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