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American Academy of Pediatrics
Article

Hypoxic-Ischemic Brain Injury: Potential Therapeutic Interventions for the Future

Aaron J. Muller and Jeremy D. Marks
NeoReviews May 2014, 15 (5) e177-e186; DOI: https://doi.org/10.1542/neo.15-5-e177
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Aaron J. Muller
*Department of Pediatrics, University of Chicago, Chicago, IL.
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Jeremy D. Marks
†Departments of Pediatrics and Neurology, University of Chicago, Chicago, IL.
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  • Abbreviations:
    eNOS,
    endothelial nitric oxide synthase
    EPO,
    erythropoietin
    H2O2,
    hydrogen peroxide
    HIE,
    hypoxic ischemic encephalopathy
    HI,
    hypoxic-ischemic
    IL,
    interleukin
    NMDA,
    N-methyl-D-aspartate
    nNOS,
    neuron-specific nitric oxide synthase
    NO,
    nitric oxide
    O2−,
    superoxide
    r-EPO,
    recombinant erythropoietin
  • Abstract

    Perinatal hypoxic-ischemic (HI) brain injury is a common problem with potentially devastating impact on neurodevelopmental outcomes. Although therapeutic hypothermia, the first available treatment for this disease, reduces the risk of death or major neurodevelopmental disability, the risk of major neurologic morbidity after HI remains significant. Basic research has identified cellular mechanisms that mediate neuronal death. This article reviews the cellular processes induced that lead to brain injury after HI, and identifies treatments currently under investigation for potential translation to clinical trials.

    • Copyright © 2014 by the American Academy of Pediatrics

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    NeoReviews
    Vol. 15, Issue 5
    1 May 2014
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    Hypoxic-Ischemic Brain Injury: Potential Therapeutic Interventions for the Future
    Aaron J. Muller, Jeremy D. Marks
    NeoReviews May 2014, 15 (5) e177-e186; DOI: 10.1542/neo.15-5-e177

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    Hypoxic-Ischemic Brain Injury: Potential Therapeutic Interventions for the Future
    Aaron J. Muller, Jeremy D. Marks
    NeoReviews May 2014, 15 (5) e177-e186; DOI: 10.1542/neo.15-5-e177
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    • Article
      • Abstract
      • Educational Gaps
      • Objectives
      • Introduction
      • Presentation of Hypoxic-Ischemic Brain Injury
      • Cellular Mechanisms of Neuronal Death After Hypoxia-Ischemia
      • New, Potential Treatments for Hypoxic-Ischemic Brain Injury
      • Conclusions
      • Footnotes
      • References
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