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American Academy of Pediatrics
Article

Genetic Approaches to Bronchopulmonary Dysplasia

Melanie Leong
NeoReviews May 2019, 20 (5) e272-e279; DOI: https://doi.org/10.1542/neo.20-5-e272
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Melanie Leong
*Division of Newborn Medicine, The Regional Neonatal Center, Maria Fareri Children’s Hospital, New York Medical College, Valhalla, NY
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  • Abbreviations:
    BPD:
    bronchopulmonary dysplasia
    GWA:
    genome-wide association
    miRNA:
    microRNA
    NICHD:
    National Institute of Child Health and Human Development
    RISC:
    RNA-induced silencing complex
    SNP:
    single nucleotide polymorphism
    VLBW:
    very-low-birthweight
  • Abstract

    Bronchopulmonary dysplasia (BPD) remains a common and challenging complication of prematurity, with limited effective strategies at the neonatologist’s disposal. Throughout the years, our understanding of this complex syndrome has broadened. Instead of solely attributing this disease to the effects of prematurity and injuries to the lung from mechanical ventilation, it is now accepted to be a multifactorial disease. Recent research efforts have focused on investigating the gene-environment interactions that may influence an infant’s susceptibility toward the development of BPD. So far, success has been limited but promising, offering hope that in the future, novel therapies will be available to ameliorate the risk for BPD.

    • Copyright © 2019 by the American Academy of Pediatrics

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    NeoReviews
    Vol. 20, Issue 5
    1 May 2019
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    Genetic Approaches to Bronchopulmonary Dysplasia
    Melanie Leong
    NeoReviews May 2019, 20 (5) e272-e279; DOI: 10.1542/neo.20-5-e272

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    Genetic Approaches to Bronchopulmonary Dysplasia
    Melanie Leong
    NeoReviews May 2019, 20 (5) e272-e279; DOI: 10.1542/neo.20-5-e272
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    • Article
      • Abstract
      • Education Gap
      • Objectives
      • Introduction
      • Twin Studies and BPD
      • Genetic Studies and BPD
      • MicroRNAs and BPD
      • Conclusion
      • Acknowledgment
      • Footnotes
      • References
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