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- FDA:
- Food and Drug Administration
- fHLH:
- familial hemophagocytic lymphohistiocytosis
- HLH:
- hemophagocytic lymphohistiocytosis
- IFNγ:
- interferon γ
- NK:
- natural killer
- sCD25/sIL-2R:
- concentration of soluble interleukin 2 receptor
- SCT:
- stem cell transplantation
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is extremely rare in the neonatal period. The incidence of neonatal HLH is not confirmed and may range from 1 in 50,000 to 150,000. The incidence varies based on ethnicity, particularly in populations in which consanguinity is common. HLH is associated with a high fatality rate and poor prognosis, making it important to recognize and diagnose it early. This review will concentrate primarily on the diagnosis and management of neonatal HLH.
- Copyright © 2019 by the American Academy of Pediatrics
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