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American Academy of Pediatrics
Article

Neonatal Hemophagocytic Lymphohistiocytosis

Josef McLean, Roia Katebian, Eugene Suh, Kamran Mirza and Sachin Amin
NeoReviews June 2019, 20 (6) e316-e325; DOI: https://doi.org/10.1542/neo.20-6-e316
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Josef McLean
Departments of *Pediatrics and
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Roia Katebian
Departments of *Pediatrics and
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Eugene Suh
Departments of *Pediatrics and
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Kamran Mirza
†Pathology, Loyola University Medical Center, Chicago, IL
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Sachin Amin
Departments of *Pediatrics and
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  • Abbreviations:
    FDA:
    Food and Drug Administration
    fHLH:
    familial hemophagocytic lymphohistiocytosis
    HLH:
    hemophagocytic lymphohistiocytosis
    IFNγ:
    interferon γ
    NK:
    natural killer
    sCD25/sIL-2R:
    concentration of soluble interleukin 2 receptor
    SCT:
    stem cell transplantation
  • Abstract

    Hemophagocytic lymphohistiocytosis (HLH) is extremely rare in the neonatal period. The incidence of neonatal HLH is not confirmed and may range from 1 in 50,000 to 150,000. The incidence varies based on ethnicity, particularly in populations in which consanguinity is common. HLH is associated with a high fatality rate and poor prognosis, making it important to recognize and diagnose it early. This review will concentrate primarily on the diagnosis and management of neonatal HLH.

    • Copyright © 2019 by the American Academy of Pediatrics

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    Vol. 20, Issue 6
    1 Jun 2019
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    Neonatal Hemophagocytic Lymphohistiocytosis
    Josef McLean, Roia Katebian, Eugene Suh, Kamran Mirza, Sachin Amin
    NeoReviews Jun 2019, 20 (6) e316-e325; DOI: 10.1542/neo.20-6-e316

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    Neonatal Hemophagocytic Lymphohistiocytosis
    Josef McLean, Roia Katebian, Eugene Suh, Kamran Mirza, Sachin Amin
    NeoReviews Jun 2019, 20 (6) e316-e325; DOI: 10.1542/neo.20-6-e316
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