Perinatal Maternal-Fetal/Neonatal Transmission of COVID-19: A Guide to Safe Maternal and Neonatal Care in the Era of COVID-19 and Physical Distancing

Marie Altendahl; Yalda Afshar; Annabelle de St. Maurice; Viviana Fajardo; Alison Chu

doi:10.1542/neo.21-12-e783

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Abbreviations:

AAP:: American Academy of Pediatrics
ACE2:: angiotensin-converting enzyme 2
CDC:: Centers for Disease Control and Prevention
COVID-19:: coronavirus disease 2019
ECMO:: extracorporeal membrane oxygenation
ICU:: intensive care unit
MERS:: Middle East respiratory syndrome
MIS-C:: multisystem inflammatory syndrome associated with COVID-19
PCR:: polymerase chain reaction
RT-PCR:: reverse transcriptase polymerase chain reaction
SARS:: severe respiratory syndrome
SARS-CoV-2:: severe acute respiratory syndrome coronavirus 2

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is highly contagious and can cause serious respiratory illness and other clinical manifestations. The aim of this review is to summarize the clinical presentation, diagnosis, and outcomes of COVID-19 in pregnant women and neonates, who may be especially vulnerable to the effects of COVID-19, and to discuss what is known about potential maternal-fetal and maternal-neonatal transmission of SARS-CoV-2.