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- EOD:
- early-onset disease
- GBS:
- group B Streptococcus
- Hib:
- Haemophilus influenzae type b
- HICs:
- high-income countries
- HIV:
- human immunodeficiency virus
- Ig:
- immunoglobulin
- LOD:
- late-onset disease
- LMICs:
- low-middle income countries
- LRTI:
- lower respiratory tract infection
- PCV:
- pneumococcal conjugate vaccine
- RSV:
- respiratory syncytial virus
- Tdap:
- tetanus-diphtheria-acellular pertussis
- TT:
- tetanus toxoid
Abstract
Newborns and infants are at risk for severe infections with some pathogens (eg, Bordetella pertussis, influenza, respiratory syncytial virus, group B Streptococcus) during early life. To decrease this window of high susceptibility to some infections during early life and protect young infants, vaccination in pregnancy against some vaccine-preventable diseases (eg, influenza, pertussis, tetanus) has been recommended in an increasing number of countries with notable success. In addition, recent advances have been made in developing vaccines for pregnant women with the aim of reducing the respiratory syncytial virus and group B Streptococcus burden in infancy. In this article, we review the vaccines currently recommended during pregnancy and their benefits to newborns and infants. We also discuss progress made in the development of other vaccines that are expected to be evaluated in pregnant women in the near future.
- Copyright © 2021 by the American Academy of Pediatrics
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In this issue
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- Article
- Abstract
- Education Gaps
- Objectives
- Introduction
- Infections During Pregnancy and Infancy: Current Targets for Maternal Immunization
- How Does Vaccination in Pregnancy Protect Infants?
- Currently Recommended Vaccines
- Modification of Infants’ Immune Responses to their own Vaccines
- Potential Protection Provided via Breastfeeding
- Future Potential Vaccines
- Conclusions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- Comments
- Quiz
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