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American Academy of Pediatrics
Article

Neonatal Nutrition and Consequences on Adult Health

Clotilde desRobert, Robert Lane, Nan Li and Josef Neu
NeoReviews May 2005, 6 (5) e211-e219; DOI: https://doi.org/10.1542/neo.6-5-e211
Clotilde desRobert
*University Medical Center of Nantes, Hôpital Mère-Enfant, Nantes, France
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Robert Lane
†University of Utah Medical School, Division of Neonatology, Salt Lake City, Utah
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Nan Li
‡University of Florida, Shands Children’s Hospitals, Gainsville, Fla
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Josef Neu
‡University of Florida, Shands Children’s Hospitals, Gainsville, Fla
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Objectives

After completing this article, readers should be able to:

  1. Describe aberrations in adult health that can result from nutrition in the fetal period and in neonatal life.

  2. Review the results of studies from human neonates regarding early nutritional interventions designed for “catch-up” growth.

  3. Review results from animal studies regarding early nutrition and “programming” for adult metabolic syndrome.

  4. Describe some of the potential epigenetic mechanisms that may be responsible for “programming.”

  5. Examine methods for preventing growth delays, the consequences of undernutrition, and the metabolic syndrome related to adverse “programming.”

Introduction

One of the traditional goals of neonatal nutrition is to maintain growth within standardized limits. In the preterm infant, growth between the 10th and 90th percentiles of intrauterine rate has been an ideal goal. More recently, maintenance of lean body mass and bone density; prevention of complications such as chronic lung disease, necrotizing enterocolitis, and infection; and optimization of neurodevelopment and adult health through early nutritional programming have become recognized as more meaningful goals than mere somatic growth.

To meet these goals, current nutritional practices require thorough scrutiny in terms of quantity and quality (composition) and how they are customized, if not for the individual patient (which would be ideal), at least for subgroups such as those who are small or appropriate for gestational age, sick or healthy, preterm or term, or male or female.

Fetal nutrition and development frequently are used as a template for the low-birthweight infant. A large body of literature on the consequences of fetal undernutrition shows that infants born small for gestational age (SGA) not only have short-term morbidity, but long-term morbidity manifested in what has been termed the “metabolic syndrome.” This syndrome includes abdominal obesity, arterial hypertension, and insulin resistance. Other clinical manifestations can be observed, including thyroid dysfunction, hirsutism, ovarian hyperandrogenism and infertility, dyslipidemia (increased …

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NeoReviews
Vol. 6, Issue 5
1 May 2005
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Neonatal Nutrition and Consequences on Adult Health
Clotilde desRobert, Robert Lane, Nan Li, Josef Neu
NeoReviews May 2005, 6 (5) e211-e219; DOI: 10.1542/neo.6-5-e211

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Neonatal Nutrition and Consequences on Adult Health
Clotilde desRobert, Robert Lane, Nan Li, Josef Neu
NeoReviews May 2005, 6 (5) e211-e219; DOI: 10.1542/neo.6-5-e211
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  • Article
    • Objectives
    • Introduction
    • Current Nutrition Practices
    • Concerns About Early Undernutrition, Overnutrition, and Catch-up Growth
    • Studies in Animals: Early Postnatal Nutrition and Adult Health
    • Approaches to Preventing Later Problems
    • Conclusions and Further Research
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