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American Academy of Pediatrics
Article

Developmental Defects in Neutrophils from Preterm Infants

Sharat Chandra, Hillary Haines, Colin Michie and Akhil Maheshwari
NeoReviews September 2007, 8 (9) e368-e376; DOI: https://doi.org/10.1542/neo.8-9-e368
Sharat Chandra
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Hillary Haines
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Colin Michie
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Akhil Maheshwari
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Abstract

Neutrophil development starts in the early second trimester in the human fetus and continues through the rest of the gestation. Preterm birth can interrupt the maturation of fetal neutrophils and place the preterm neonate at risk of life-threatening infections. Various developmental defects have been identified in preterm neutrophils, such as in the ability of circulating neutrophils to cross the endothelial barrier and abnormalities in chemotaxis, respiratory burst, and degranulation. The availability of recombinant human myeloid growth factors has renewed interest in understanding the mechanisms and natural history of such defects. In this article, we review various aspects of the developmental immaturity of preterm neutrophils.

  • Copyright © 2007 by the American Academy of Pediatrics

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NeoReviews
Vol. 8, Issue 9
1 Sep 2007
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Developmental Defects in Neutrophils from Preterm Infants
Sharat Chandra, Hillary Haines, Colin Michie, Akhil Maheshwari
NeoReviews Sep 2007, 8 (9) e368-e376; DOI: 10.1542/neo.8-9-e368

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Developmental Defects in Neutrophils from Preterm Infants
Sharat Chandra, Hillary Haines, Colin Michie, Akhil Maheshwari
NeoReviews Sep 2007, 8 (9) e368-e376; DOI: 10.1542/neo.8-9-e368
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  • Article
    • Abstract
    • Objectives
    • Introduction
    • Neutrophil Kinetics
    • Recruitment of Circulating Neutrophils to Sites of Inflammation
    • Chemotaxis
    • Phagocytosis
    • Killing
    • Degranulation
    • Cytokine Production
    • Resolution of the Inflammatory Response
    • Antibody-dependent Cellular Cytotoxicity
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