PT  - JOURNAL ARTICLE
AU  - Abu-Raya, Bahaa
AU  - Maertens, Kirsten
TI  - Protection of the Newborn Through Vaccination in Pregnancy
AID  - 10.1542/neo.22-1-e25
DP  - 2021 Jan 01
TA  - NeoReviews
PG  - e25--e39
VI  - 22
IP  - 1
4099  - http://neoreviews.aappublications.org/content/22/1/e25.short
4100  - http://neoreviews.aappublications.org/content/22/1/e25.full
SO  - NeoReviews2021 Jan 01; 22
AB  - Abbreviations:EOD: early-onset diseaseGBS: group B StreptococcusHib: Haemophilus influenzae type bHICs: high-income countriesHIV: human immunodeficiency virusIg: immunoglobulinLOD: late-onset diseaseLMICs: low-middle income countriesLRTI: lower respiratory tract infectionPCV: pneumococcal conjugate vaccineRSV: respiratory syncytial virusTdap: tetanus-diphtheria-acellular pertussisTT: tetanus toxoidNewborns and infants are at risk for severe infections with some pathogens (eg, Bordetella pertussis, influenza, respiratory syncytial virus, group B Streptococcus) during early life. To decrease this window of high susceptibility to some infections during early life and protect young infants, vaccination in pregnancy against some vaccine-preventable diseases (eg, influenza, pertussis, tetanus) has been recommended in an increasing number of countries with notable success. In addition, recent advances have been made in developing vaccines for pregnant women with the aim of reducing the respiratory syncytial virus and group B Streptococcus burden in infancy. In this article, we review the vaccines currently recommended during pregnancy and their benefits to newborns and infants. We also discuss progress made in the development of other vaccines that are expected to be evaluated in pregnant women in the near future.