PT  - JOURNAL ARTICLE
AU  - McLean, Josef
AU  - Katebian, Roia
AU  - Suh, Eugene
AU  - Mirza, Kamran
AU  - Amin, Sachin
TI  - Neonatal Hemophagocytic Lymphohistiocytosis
AID  - 10.1542/neo.20-6-e316
DP  - 2019 Jun 01
TA  - NeoReviews
PG  - e316--e325
VI  - 20
IP  - 6
4099  - http://neoreviews.aappublications.org/content/20/6/e316.short
4100  - http://neoreviews.aappublications.org/content/20/6/e316.full
SO  - NeoReviews2019 Jun 01; 20
AB  - Abbreviations:FDA: Food and Drug AdministrationfHLH: familial hemophagocytic lymphohistiocytosisHLH: hemophagocytic lymphohistiocytosisIFNγ: interferon γNK: natural killersCD25/sIL-2R: concentration of soluble interleukin 2 receptorSCT: stem cell transplantationHemophagocytic lymphohistiocytosis (HLH) is extremely rare in the neonatal period. The incidence of neonatal HLH is not confirmed and may range from 1 in 50,000 to 150,000. The incidence varies based on ethnicity, particularly in populations in which consanguinity is common. HLH is associated with a high fatality rate and poor prognosis, making it important to recognize and diagnose it early. This review will concentrate primarily on the diagnosis and management of neonatal HLH.