PT  - JOURNAL ARTICLE
AU  - Chandra, Sharat
AU  - Haines, Hillary
AU  - Michie, Colin
AU  - Maheshwari, Akhil
TI  - Developmental Defects in Neutrophils from Preterm Infants
AID  - 10.1542/neo.8-9-e368
DP  - 2007 Sep 01
TA  - NeoReviews
PG  - e368--e376
VI  - 8
IP  - 9
4099  - http://neoreviews.aappublications.org/content/8/9/e368.short
4100  - http://neoreviews.aappublications.org/content/8/9/e368.full
SO  - NeoReviews2007 Sep 01; 8
AB  - Neutrophil development starts in the early second trimester in the human fetus and continues through the rest of the gestation. Preterm birth can interrupt the maturation of fetal neutrophils and place the preterm neonate at risk of life-threatening infections. Various developmental defects have been identified in preterm neutrophils, such as in the ability of circulating neutrophils to cross the endothelial barrier and abnormalities in chemotaxis, respiratory burst, and degranulation. The availability of recombinant human myeloid growth factors has renewed interest in understanding the mechanisms and natural history of such defects. In this article, we review various aspects of the developmental immaturity of preterm neutrophils.