Table 5.

Basis for Dosing Clonidine in Neonatal Abstinence Syndrome (14)(19)

IndicationInitial DoseTitrationMaintenance Dose
Analgesia (continuous infusion)0.5 μg/kg/h IVAdjust cautiously based on clinical effect0.5 to 2 μg/kg/hour
Neuropathic pain2 μg/kg/dose PO every 4 to 6 hIncrease incrementally over several days2 to 4 μg/kg per dose every 4 to 6 h
Neonatal Abstinence Syndrome0.5 to 1.5 μg/kg POIncrease over 1 to 2 d to target dose3 to 5 μg/kg per day divided every 4 to 6 h
  • IV=intravenous, PO=oral